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Vitamin and Mineral Overview   |   Inositol - Depression and stress buster   |   Gaba-Pain, Depression and focus   |   Choline - Mind mood and attitude   |   Magnesium The hidden deficiency the greater benefit   |   Taurine - Bi Polar, ADD, Diabetes and so much more   |   Alpha Lipoic Acid (ALA)  produce energy   |   Lysine - Fat, collagen, injury recovery and your lungs too read more   |   Glutamine - the anti-anxiety amino acid   |   Magnesium the missing link to health
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Choline - Mind mood and attitude


It is well established that supplements of methyl group transfer vitamins B6, B12, folic acid reduce the blood titer of homocysteine and prevent heart disease. Choline is a necessary source of methyl groups for methyl group transfer. Supplements of lecithin/choline reduced heart disease in laboratory studies. The reduction in heart disease with lecithin supplements may however relate more to the cholesterol carrying capacity of lecithin than to the methyl group transfer role of choline.

Choline supplements are often taken as a form of 'smart drug' or nootropic, due to the role that the neurotransmitter acetylcholine plays in various cognition systems within the brain. Choline is a chemical precursor or "building block" needed to produce the neurotransmitter acetylcholine, and research suggests that memory, intelligence and mood are mediated at least in part by acetylcholine metabolism in the brain. The compound's quaternary amine renders its lipid insoluble which might suggest it would be unable to cross the blood-brain barrier. However, despite choline's lipid insolubility, a choline transporter exists that allows transport across the blood-brain barrier. The efficacy of these supplements in enhancing cognitive abilities is a topic of continuing debate.

Lakhan & Vieira (2008) link choline deficiency to bipolar disorder and report efficacy in lecithin supplementation based on a double-blind, placebo controlled trial.

Some people who practice lucid dreaming use Galantamine with choline bitartrate or Alpha GPC to increase their odds of having a lucid dream. Acetylcholine precursors such as choline work synergistically with Galantamine to help improve memory and the symptoms of Alzheimer's Disease (AD).

The Food and Drug Administration (FDA) requires that infant formula not made from cow's milk be supplemented with choline.

Due to its role in lipid metabolism, choline has also found its way into nutritional supplements which claim to reduce body fat; but there is little or no evidence to prove that it has any effect on reducing excess body fat or that taking high amounts of choline will increase the rate at which fat is metabolised.

Because of its importance in fat metabolism, choline status is important to evaluate in virtually all health problems involving the liver, including alcoholism and cirrhosis. Epilepsy, Parkinson's disease, Alzheimer's disease, memory deficit problems, attention deficit and hyperactivity disorders, neuromuscular disorders, cardiovascular diseases (especially coronary heart disease), brain disorders, autism, failure to thrive in newborns, respiratory distress in newborns, hypertriglyceridemia, hyperhomocysteineimia, anemia, infertility, high blood pressure, and candidiasis all justify a close look at choline adequacy.
Along with the other SAM cycle nutrients, choline status may also be important to consider in reducing the toxic effects of heavy metals in the body, including lead. Although the exact role for choline in helping protect against heavy metal toxicity is not clear, the process is definitely not a simple one merely involving the methylation of heavy metals. The attaching of methyl groups to heavy metals often increases, rather than lowers, their toxicity.

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