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Glutamine - the anti-anxiety amino acid

L- Glutamine




Glutamine is, Master protein builder, gut restorer,
the third most abundant amino acid in the blood and brain. It is an inhibitory neurotransmitter that acts as a precursor for GABA, the anti-anxiety amino acid. Glutamine crosses the blood-brain barrier where it helps increase energy and mental alertness. It helps the brain dispose of waste ammonia, a protein breakdown byproduct. Glutamine's most important function is strengthening the immune system due to its effects on increasing white blood cells. It also aids other immune cells in killing bacteria, healing wounds and maintaining and supporting Glutathione, an important antioxidant. The main nutrient needed for intestinal repair is glutamine, which can work with Leaky-Gut syndrome. It is a tasteless powder that can help curb sugar and alcohol cravings. Children born with a Glutamine deficiency are more prone to alcoholism later in life. Glutamine also is one of the most potent Growth Hormone stimulators.

In Dr. Richard Klatz's book, Grow Young with HGH, Dr. Giampapa is quoted reporting that two grams of
glutamine are more potent than one gram of Arginine, Ornithine and Lysine combined.


Taking L- Glutamine with the following is a powerful combination not only for substance addiction but for depression and pain.



GABA

Dr. Candace Pert,Pharmacologist, discovered the GABA receptor sites throughout the brain and body.

Nicknamed
“The Anti-Anxiety Amino Acid,” this is an
inhibitory neurotransmitter that the brain uses to
stop the endless cycle of stress, which is so
common in today's world. While there is no such
thing as a tranquilizer deficiency, most people
who have abused refined carbohydrates
(especially alcohol and sugar) as well as those
who have been chronically emotionally or
mentally fatigued are greatly lacking in this
nutrient. GABA can be of great help in those who
can't get to sleep because of an overly stimulated
mind. Many allopathic anti-depressants have the
effect on the human body of substituting
depression for irritability, which is why some
people are given prescriptions for tranquilizers
along with anti-depressants. This nutrient may
greatly help. Remember that GABA requires B Complex Vitamins for its proper assimilation.

DLPA - DL-Phenylalanine

Endorphins regulate pain and control the
transmission of pain signals. Endorphins are inhibitory neurotransmitters in the brain and nervous system. Endorphins slow down paintransmission signals.

Safe, no negative side effects for most people.**
Effective for acute or chronic conditions. Easy on
the stomach. Non-narcotic or habit-forming.
Supports body's endorphins, the natural
morphine (pain killers) found in the brain. DLPA
helps extend the endorphin's lifespan so you get
relief.

GLUTAMINE:
Glutamine, the most abundant protein constituent in the body, may also be the most important. The secret to its significance is that it provides nitrogen more readily than any other amino acid. From treating intestinal maladies to calming addictive urges, few other substances offer as much to nutritional medicine.

To recover successfully from any of a variety of illnesses and injuries, the body needs certain proteins. No matter which are needed, all can be made with the help of L-glutamine. It possesses an extra nitrogen atom, which it readily offers for the synthesis of other amino acids. In this way it works as a kind of molecular Robin Hood that directs the distribution of our amino acid riches. In this "nitrogen shuttle," as it's called, glutamine
takes proteins from where it can be spared and delivers them to where they are most needed. In addition, it
helps the body create other important nutrients, such as glutathione, glucosamine, and vitamin B3.
Intestinalfortitude : Glutamine maintains the structural integrity of the intestines to such an extent that it has
been dubbed "intestinal permeability factor." No other nutrient is as important for gastrointestinal health.

Patient with a severe intestinal or inflammatory bowel condition gets a healthy daily dose of glutamine. Even though its primary benefit is directed to the small intestine, it rapidly facilitates healing and restores the health of mucous membranes inside the colon (large intestine). I first learned about its gastrointestinal impact from Judy Shabert, M.D., R.D., and her husband, Douglas Wilmore, M.D., a Harvard researcher investigating the value of the amino acid before and after surgery.   The nutrient's usefulness was recognized some forty years ago, when it was used in a dosage of just 1.6 grams per day, to treat peptic ulcers.  Much more recently, research proved that supplementation lessens stomach inflammation caused by chemotherapy and can be useful in treating diarrhea.

Surgical Recovery. Following an operation or any other physically stressful event, the body can't synthesize enough glutamine to heal wounds, preserve lean tissue, and nourish the immune system, among other needs. After draining its reserves, the body must then draw from muscles and the branched-chain amino acids. Providing supplemental glutamine avoids all of these complications, normalizes the amino acid levels, speeds the healing of wounds and burns, and improves overall surgical recovery. People whose intravenous feedings included glutamine also developed fewer complications, were discharged sooner, and paid about $21,000 less in hospital bills.

Immune System Assaults. The immune system's primary source of energy is glutamine. While always high, the need for fuel skyrockets whenever we're subjected to stress, trauma, or injury. Many forms of cancer, for instance, deplete the body of glutamine, one reason that people with the disease lose lean tissue and muscle mass. Polyps in the colon, a major precancerous lesion, have a significantly lower glutamine content than the healthy tissue around them.  Supplementation shields the liver from chemotherapy's toxic side effects, animal studies show, and might strengthen the cancer-killing ability of certain chemotherapeutic drugs. Viral infections also deprive the immune system of glutamine. When our reserve is low, a standard measurement of immune activity, the number of T cells declines, while our toxic particle-attacking white blood cells, called macrophages, lose strength.  But when L-glutamine is given in dosages of 20-40 grams daily, the immune system responds, as demonstrated by the extra infection safeguard it provided in studies of patients with bone marrow transplants. For all these reasons, glutamine is an essential treatment for AIDS or viral chronic fatigue syndrome.

Liver Diseases. Glutamine can inhibit fatty buildups inside the liver and aid treatment of cirrhosis.  However, in the very late stages of liver failure, the advantage is lost, because the organ no longer can handle glutamine effectively.    

Addictions. Long before we knew about its involvement in tissue repair, I was using glutamine to help control cravings. I got the idea from Roger Williams, Ph.D., the nutritionist who inspired so many of us to pursue nutritional medicine. He used glutamine to curb the desire to drink alcohol,which it does quite well. A daily dose of 12 grams (about 3 teaspoons) did the job for 75 percent of the people studied in one experiment.

Adapting the treatment to my practice, I decided to try the amino acid with my many patients who crave sweets. It worked, and it will probably work for you, too.

When a sugar urge emerges, take 1-2 grams of L-glutamine, preferably with some heavy cream and just a touch of nonsugar sweetener. The immediate desire to eat something sweet will pass.  It was quite gratifying to read not long ago that a research director at the National TypeInstitute of Mental Health also acknowledged glutamine's influence on sugar cravings.
Obesity. It is possible that glutamine may help weight loss through other mechanisms. In addition to preserving lean tissue, which contributes to burning off fat, the amino acid helps cleanse the body and liver of waste products that are created by fat metabolism. It's also a readily available,carbohydrate-free energy source if you drastically cut your calorie consumption.

Mental Instability. Glutamine is the great natural balancer of excitement and lethargy. It's a major source of energy for the brain and an important building block for several neurotransmitters. Though some critics correctly note that the body may convert glutamine into glutamic acid, a so-called excitotoxin that overly stimulates and agitates brain cells, they fail to recognize that glutamine can also be converted to GABA, a natural brain tranquilizer that calms hyperactive cells. Nature wisely allows the body to manufacture either GABA or glutamic acid on an as-needed basis.    

Exercise Recovery. The repair and preservation of muscle tissue makes glutamine a popular supplement among weight lifters and other dedicated athletes. Prolonged exercise causes microscopic injuries to the muscles and, for as long as two weeks after a workout, lowers the body's glutamine stores.16 Taking supplements feeds the need for and replenishes the supply of glutamine, but that's not all. The extra nitrogen allows the body to build more lean tissue and helps fill stockpiles of glycogen, the form of carbohydrate stored in muscles and the liver for use during physical activity.   With enough glycogen on hand, less muscle tissue is broken down for energy. The amino acid also promotes the release of growth hormone, which can spur muscle growth.

Don't expect to look like Mr. Universe, if that's your goal, simply by using supplements. And if you're taking glutamine for some other medical reason, don't worry about sprouting bulky bulges of muscle. The average person just maintains a healthy pace against the constant turnover of muscle tissue that occurs through normal metabolism. Gains are modest and hard earned,noticeable only with strenuous resistance training.     .
supplement suggestions

Powdered L-glutamine is the easiest and most economical way to take the amino acid. A daily teaspoon, about the equivalent of 5 grams, is useful for maximizing gains from a weight-lifting program. Treating disease demands far greater amounts, and the more severe the illness, the  higher the dosage you should take.     

To stimulate the immune system you'll need between 5 and 20 grams per day. Between 2 and 3 grams will suffice for counteracting a desire for alcohol or sugar. Take it as soon as the urge comes to mind. As a treatment for inflammatory bowel disease or leaky gut syndrome, I've prescribed as much as 40 grams a day.
A similar amount could be required for wound healing or recovery from a prolonged hospital stay. These dosages are very safe; none of my patients have ever developed side effects.















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