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Pure Herbs Ashwagandha

4 ounce  $42.75

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oral chelation

joint pain, sports injury
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Also called: Withania somnifera, Indian Ginseng, Avarada, and Withania.

Here is an article I was given and do not have the authors name as to give credit.  
It is very good and comprehensive.
Pure Herbs Ashwagandha dosages is as follows:  

DOSE: 40 drops or more (3) times per day or as needed to achieve desired results. Helps alleviate mental fatigue by inhibiting an enzyme (acetyl-cholinesterase) that degrades acetylcholine in the aging brain.

Not much research has been carried out for this particular botanical and to date there have not been any released notes on possible medicinal contraindications, side effects or potential health hazards. This particular root has been used successfully for the last 3,000 years and the empirical evidence of the ages speaks for itself. It comes highly recommended in times of severe strife and stress-induced discomfort. However Ashwagandha should not be consumed for long periods of time and is better reserved for the "times of need".

Main points I gleaned from the article that are simply amazing.

Ashwagandha,  stress-relieving properties
Protective effects on the nervous system
alternative treatment for Alzheimer's and Parkinson's
antioxidant properties that seek and destroy the free radicals
evidence suggests  ashwagandha has anti-cancer benefits as well
relieve stress,  anti-stress agent.
protect brain cells against the deleterious effects of our modern lifestyles
abolished Premature aging associated with chronic nervous tension
reported increased energy, reduced fatigue, better sleep, and an enhanced sense of well-being
reduction of cortisol levels up to 26%
a decline in fasting blood sugar levels
improved lipid profiles.
significant regeneration of the axons and dendrites of nerve cells
ashwagandha could help heal the brain tissue changes that accompany dementia
supported the reconstruction of synapses, the junctions where nerve cells communicate with other cells
extract helps to reconstruct networks of the nervous system, making it a potential treatment for neurodegenerative diseases such as Alzheimer's
chronic neurodegenerative conditions vastly improved for which there currently are no cures
extract inhibits acetylcholinesterase, an enzyme responsible for breaking down one of the brain's key chemical messengers
potential to stop cancer cells in their tracks
ashwagandha extract disrupts cancer cells' ability to reproduce
ashwagandha extract produced a marked increase in life span and a decrease in tumor weight in animals with experimentally induced cancer of the lymphatic system
ashwagandha could enhance survival in individuals with cancer
Powerful Protective Effects on the Nervous System
Stress, environmental toxins, and poor nutrition all have a detrimental impact on our nervous systems.
ashwagandha has been demonstrated to be as effective as some tranquilizers and antidepressant drugs.
Specifically, oral administration of ashwagandha for five days suggested anxiety-relieving effects similar to those achieved by the anti-anxiety drug and antidepressant effects.

Stress increases peroxidation of lipids, while decreasing levels of the antioxidant enzymes catalase and glutathione peroxidase. Ashwagandha administered by re-searchers one hour before a daily stress-inducing procedure, all of the aforementioned parameters of free radical damage normalized in a dose-dependent manner.

 Premature aging associated with chronic nervous tension may be related to increased oxidative stress, which is abolished by the potent antioxidant properties of ashwagandha extract.

Researchers believe this finding supports the clinical use of ashwagandha as an anti-stress agent.

Remarkable animal study, examination of the brains of sacrificed animals showed that 85% of the brain cells observed in the animals exposed to chronic stress showed signs of degeneration. It is this type of cellular degeneration that can lead to long-term cognitive difficulties. Amazingly, when ashwagandha was administered to chronically stressed animals, the number of degenerating brain cells was reduced by 80%!

In one of the most complete human clinical trials to date, researchers studied the effects of a standardized extract of ashwagandha on the negative effects of stress, including elevated levels of the stress hormone cortisol. Many of the adverse effects of stress are thought to be related to elevated levels of cortisol.

The results were impressive. The participants subjectively reported increased energy, reduced fatigue, better sleep, and an enhanced sense of well-being. The participants showed several measurable improvements, including a reduction of cortisol levels up to 26%, a decline in fasting blood sugar levels, and improved lipid profiles. It would appear from this study that ashwagandha can address many of the health and psychological issues that plague today's society.

Over the past five years, the Institute of Natural Medicine at the Toyama Medical and Pharmaceutical University in Japan has conducted extensive research into the brain benefits of ashwagandha. The Institute's scientists were looking for ways to encourage the regeneration of nerve cell components called axons and dendrites in validated models of the human brain. This important research may one day benefit those who have incurred brain injuries due to physical trauma, as well as those who suffer cognitive decline due to destruction of the nerve cell networks from diseases such as dementia and Alzheimer's.

Using a validated model of damaged nerve cells and impaired nerve-signaling pathways, re-searchers noted that ashwagandha supported significant regeneration of the axons and dendrites of nerve cells. Furthermore, ashwagandha extract supported the reconstruction of synapses, the junctions where nerve cells communicate with other cells. The investigators concluded that ashwagandha extract helps to reconstruct networks of the nervous system, making it a potential treatment for neurodegenerative diseases such as Alzheimer's.

In another study at the same institute, researchers found that ashwagandha helped support the growth of nerve cell dendrites, which allow these cells to receive communications from other cells. This finding suggests that ashwagandha could help heal the brain tissue changes that accompany dementia.

Finally, in a third published study, the researchers noted that ashwagandha helped promote the growth of both normal and damaged nerve cells, suggesting that the herb may boost healthy brain cell function as well as benefit diseased nerve cells.

These findings provide tremendous hope that ashwagandha extracts may one day help heal neurodegenerative diseases in humans, freeing patients from the mental prisons of dementia and Alzheimer's. Clearly, this is just the beginning of research into ashwagandha's ability to encourage physical re-growth of the brain.

Ashwagandha also shows promise as a treatment for Parkinson's and Alzheimer's diseases, chronic neurodegenerative conditions for which there currently are no cures. In a recent study using a standardized model of human Parkinson's disease, ashwagandha extract reversed all the parameters of Parkinson's-type neurodegeneration significantly and in a dose-dependent manner.

Remarkably, an earlier study showed that ashwagandha extract inhibits acetylcholinesterase, an enzyme responsible for breaking down one of the brain's key chemical messengers. Drugs currently used in the treatment of Alzheimer's disease, such as Aricept®, act in this very manner to slow the progression of this frightening, mind-robbing disease.
Studies Suggest Potent Anti-Cancer Activity
In addition to ashwagandha's documented neuroprotective effects, exciting recent evidence suggests that it also has the potential to stop cancer cells in their tracks. For example, a recent analysis showed that ashwagandha extract inhibited the growth of human breast, lung, and colon cancer cell lines in the laboratory.

This inhibition was comparable to that achieved with the common cancer chemotherapy drug doxorubicin (Caelyx®, Myocet®). In fact, researchers reported that withaferin A, a specific compound extracted from ashwagandha, was more effective than doxorubicin in inhibiting breast and colon cancer cell growth.

Scientists in India recently conducted cell studies showing that ashwagandha extract disrupts cancer cells' ability to reproduce-a key step in fighting cancer.

Additionally, laboratory analysis indicates that ashwagandha extract possesses anti-angiogenic activity, also known as the ability to prevent cancer from forming new blood vessels to support its unbridled growth. These findings lend further support to ashwagandha's potential role in fighting cancer.

Based on these studies, research in this area continues.

In another study, orally administered ashwagandha extract significantly inhibited experimentally induced stomach cancer in laboratory animals. Tumor incidence was reduced by 60% and tumor multiplicity (number) by 92%. Similarly, in a rodent model of skin cancer, ashwagandha inhibited tumor incidence and multiplicity by 45% and 71%, respectively.16 Ashwagandha's protective effect against skin cancer has been shown in other studies as well.

A recent experiment demonstrated that ashwagandha extract produced a marked increase in life span and a decrease in tumor weight in animals with experimentally induced cancer of the lymphatic system.

 This is an exciting finding, suggesting that ashwagandha could enhance survival in individuals with cancer.

Ashwagandha Safety and Toxicity
In a study of rats for intake of ginseng and ashwagandha for 90 days, researchers found significant increase in body
weight, food consumption and liver weight, and improved hematopoiesis. They did not reveal any toxicity of brain, heart,
lung, liver, spleen, kidneys, stomach, testis and ovaries. [17] Thus, ashwagandha probably is safe without serious side

Ashwagandha Side Effects
Ashwagandha probably is safe for most healthy people when taken by mouth for short-term use. The side effects of large dosage of ashwagandha may include stomach upset, diarrhea and vomiting, while the side effects of long-term use is unknown.

There is a case about ashwagandha side effect. The reporter speculated that ashwagandha could increase serum
concentrations of thyroid hormones causing thyrotoxicosis of a healthy woman. Chronic fatigue is the one of the main
symptoms of thyrotoxicosis. The symptoms resolved spontaneously after discontinuation of the ashwagandha capsules.

Panda S and Kar A from D.A. University, Indore, India noticed that ashwagandha root extracts could regulate thyroid
function with special reference to type-I iodothyronine 5'-monodeiodinase activity in mice liver. Furthermore,
ashwagandha root extract significantly reduced hepatic lipid peroxidation, whereas the activity of antioxidant enzymes
such as superoxide dismutase and catalase were increased. These findings reveal that the ashwagandha root extract
stimulates thyroidal activity and also enhances the antiperoxidation of hepatic tissue. [16]

People with thyroid or liver issues should not use this herb or related products. Also, ashwagandha has immunological
effects, people with auto-immune diseases should not take ashwagandha. Auto-immune diseases include multiple
sclerosis, lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis, etc.

I had not seen nor heard of such effects with tincture of ashwagandha. I am sending this as a consideration. Take the tincture once a week only until you see how you react. I have never heard of this but I was doing another study research on hyperthyroidism and came across this.

I re reviewed my master herblism information on this and found no such information.
I believe in being proactive and wanted to be sure you have this to be fully informed. I still believe in ashwagandha. Caution is always a must. These issues below were all capsules and not tincture form.
~ Adelle

Ashwagandha side effects, safety, risk, danger
Ashwagandha herb does not seem to have any significant side effects but long term studies are not yet available to determine ashwagandha side effects from chronic use. Nevertheless, it is best to take breaks from use. For instance, one can take a week off each month or take it 3 or 4 times a week as opposed to daily. There is one case report from Holland of a person taking high doses for prolonged periods who ended up with excessive thyroid hormone production.

Effect on thyroid gland
My name is Rudger Hogeveen, from Netherlands. am a medical student in Holland. Recently I read an article in a Dutch medical journal regarding ashwagandha and thyroid gland. In this journal was a case report about an patient who had thyrotoxicosis after chronic ashwagandha supplement use.
Ned Tijdschr Geneeskd. 2005: Thyrotoxicosis following the use of ashwagandha. Inspectie voor de Gezondheidszorg, sectie Geneesmiddelenbewaking, Postbus Den Haag.

A 32-year-old healthy woman developed thyrotoxicosis while taking capsules that contained ashwagandha herbal extract for symptoms of chronic fatigue. She was not taking any other remedies or medications. During the first few weeks, she took the capsules only occasionally without any symptoms, but after increasing the dose, she experienced clinical symptoms indicative of thyrotoxicosis. This was confirmed by laboratory assessment. The symptoms resolved spontaneously after discontinuation of the ashwagandha capsules and laboratory values normalised. Data from animal studies, however, have suggested that ashwagandha can increase serum concentrations of thyroid hormones. This case study suggests that excess thyroid hormone effects is a potentially serious side effect of ashwagandha. Note: Rudger Hogeveen approved his name being mentioned.

I have been suffering from a thyroid condition for several years and am taking Synthroid with some benefit, but still am symptomatic despite lab levels which are in the target range. An herbal specialist who recommended ashwahgandha. I did feel significantly better on this supplement, my hair loss stopped, my libido returned, etc, however, I am experiencing some problems with symptoms of increased thyroid production. Because I am finally feeling better/normal for the first time in years, I would like to find a way to perhaps taper my Synthroid and stay on the ashwagandha (since it may enhance thyroid hormone production). my current endocrinologist knows nothing about herb / Ayurvedic medicine.

The influence of ashwagandha on thyroid function is still being evaluated and there is very little research on the topic, including what the appropriate dosage would be for the long term and how such supplements interact wish Synthroid or other thyroid medications.

I started taking ashwagandha capsules for the past 2 months. Last year I got my T3, T4, TSH tested and they were all normal. And now when tested again T3, T4, Ft4 are all normal but TSH is abnormal 13.9. I don't have any symptoms of hypothyroidism and still my blood reports TSH have come out positive. When consulted doctors, they asked me to get on medication Thyronorm 50mg for now. I read that ashwagandha can cause hyperthyroidism. My family has no background of any thyroid dysfunction. All of a sudden I have TSH elevated to high level and this is bothering me a lot. Now my doubt is can ashwagandha also cause hypothyroidism ? Should I stop taking the capsules. Also should I start medication for hypothyroidism or wait for now.

I can't give specific treatment advice but your doctor may wish to read this page.
I have Hashimoto's thyroiditis and when I began the herbal product I was hyperthyroid. After a couple days I felt better, much calmer, more relaxed, etc. I did have to make a slight increase in my Methimazole (anti-thyroid medication) to compensate for what I thought was the mild thyrotoxic effects of ashwagandha. After about 6 weeks of continued daily use, my thyroid blew up. I could not sleep, and had all of the symptoms of severe hyperthyroidism. I had forgotten about the herb's potential to cause thyrotoxicosis, but "re-discovered" it, and stopped. I had to take very high doses of the Methimazole while experiencing the thyrotoxicosis. Once I stopped the ashwaganda, my thyroid appeared to normalize to its previous state after about 5 days. Then after another few days, it went very hyper once again. It did finally settle down to the normal range after a couple of weeks as confirmed by blood tests. It is now a couple months later, and I am borderline hyperthyroid. I am just letting you know, so you can warn others about ashwaganda and the danger it can present. I want to also state that your website is very informative and actually was the site that made me recall that ashwaganda can cause thyrotoxicosis. I feel that the information provided is great because it promotes a cautious approach when using supplements, as there have not been adequate studies on them. You are doing a great service for the public.

I find it very interesting and trustworthy to read about various supplements on your site. I have had some mild anxiety and mood disturbances for a while so I decided to try ashwagandha 300 mg of the whole herb, not an extract. I have read on your page that it can interfere with thyroid function. When i have been to the doctor before i asked to have my thyroid checked. I had a normal TSH and a T4 that was in the high normal range. I really want to take this herb. Obviously i am not hyperthyroid since tests are normal and symptoms are non existent. So my question is it so powerful that 300 mg of the whole herb per day can make the thyroid go hyperthyroid?

It is unlikely that small amounts of the herb will have a strong influence on thyroid hormone levels, but it is difficult to predict in any one individual what would occur.

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